| InteguSeal* Microbial Sealant: an Essential Tool in the Fight Against Surgical Site Infections |
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| Prepping and draping are important parts of your pre-op routine, but no prep protocol can completely sterilize a patient’s skin. It’s the pathogens left behind that are the leading cause of surgical site infections.1 And those are the pathogens that InteguSeal* is designed to handle.
InteguSeal* Microbial Sealant is proven to seal and immobilize the bacteria that survive prep, including MRSA, S. epidermidis, and E. coli—preventing them from contaminating the surgical incision. |
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| The Centers for Disease Control (CDC) states that“for most SSIs, the
source of pathogens is the endogenous Row of the patient ’s skin, mucous
membranes, or hollow viscera.”1 |
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| InteguSeal* is a sterile, film-forming cyanoacrylate liquid, provided in a ready-to-use applicator. It is applied to the skin over commonly-used surgical skin preparation products, including iodophors and 2% CHG, prior to a surgical incision. |
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Upon contact with the prepped skin, the moisture and proteins present in the stratum corneum cause the liquid monomer in InteguSeal* to polymerize into a thin, flexible film which bonds to the skin surface, including skin contours, hair follicles and sweat glands. This breathable film immobilizes bacteria which survive the conventional surgical skin preparation and rebound during surgery, preventing migration or transference into the incision.
InteguSeal* has a unique mechanism of action which reduces skin Row contamination by physically immobilizing microorganisms-- not by antimicrobial activity. InteguSeal* has been tested against a wide range of pathogens, including Methicillin-resistant S. aureus (MRSA) and has been shown to be equally effective at immobilizing all types of bacteria without regard to antimicrobial susceptibility. Use of InteguSeal* Microbial Sealant does not contribute to antimicrobial resistance |
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| InteguSeal* Is Effective against Common and Dangerous Skin Pathogens |
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| In vitro studies have demonstrated the ability of InteguSeal* to immobilize methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis and E.coli on skin incision models. |
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| Topical application of InteguSeal* Microbial Sealant significantly reduced the amount of MRSA recovered from inoculated skin in an in vitro surgical incision
model by 99.9%, S. epidermidis by 99.5% and E. coli by 96.6% (p ≤ 0.05). The differences in mean microbial recovery from skin inoculated with InteguSeal* and untreated skin were statistically significant (p ≤ 0.05) for all three bacteria tested. |
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| InteguSeal* Is Effective Throughout a Surgical Procedure |
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| Unlike skin preps which can be washed off by irrigation or body fluids during surgery, InteguSeal* forms a protective layer which stays in place throughout even extended procedures. Compared to plastic incise drapes, which can trap air and moisture and actually encourage regrowth of skin flora2, InteguSeal seals over all skin contours, hair, and even micro-abrasions, to lock endogenous pathogens in place and prevent transference to the incision site.
A controlled in vivo porcine study proved the effectiveness of InteguSeal* at reducing the risk of skin flora contamination throughout a surgical procedure. |
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| In a simulated surgical environment, all surgical sites were treated with 10% povidone iodine prep and treated with either InteguSeal* Microbial Sealant or an antimicrobial incise drape. A full-thickness incision was made, followed by a 60-minute surgical procedure involving wound retraction, simulated surgical manipulations and wound lavage. |
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| Incisions were sampled for bacterial contamination at two points: after incision and prior to wound closure. Significantly fewer colony forming units of bacteria were recovered before wound closure in the samples treated with InteguSeal* as compared to the samples treated with antimicrobial incise drapes (p<0.002). |
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InteguSeal* is intended to remain on the skin following the completion of the surgical procedure. The incision is closed and dressed according to existing standards of care and removal of InteguSeal* is not required. Following surgery, InteguSeal* naturally sloughs off the skin over the course of a few days. |
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| InteguSeal* is Available in 3 Sizes for a Full Range of Procedures |
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- InteguSeal* IS100 provides coverage of surgical sites up to approximately 100 in2. (25cm x 25cm)
- InteguSeal* IS200 covers approximately 200 in2. (50cm x 25cm).
- InteguSeal* IS50 is designed for smaller incision sites, with coverage up to approximately 50 in2. (12cm x 25cm), and comes in a smaller applicator for use in confined area
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